Membrane Transport Proteins with Complete Replacement of Transmembrane Helices with Polyalanine Sequences Remain Functional
نویسندگان
چکیده
منابع مشابه
Membrane transport proteins with complete replacement of transmembrane helices with polyalanine sequences remain functional.
Approximately 25% of all genome coding sequences correspond to membrane proteins, which perform varied and essential functions in cells. Eukaryotic integral membrane proteins are predominantly alpha-helical proteins that span the membrane several times. The most frequent approach to identifying transmembrane-helix amino acids essential for function is to substitute native residues, one at a tim...
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Many sophisticated methods have been applied to the prediction of structure and function of protein sequences which are derived from the genome projects. However, difficulties of prediction for some protein types, e.g., membrane proteins, are not still resolved due to the lack of their 3D structure information. Although membrane proteins are minor fraction of the genome, the biological function...
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متن کاملClassi cation of Membrane Proteins by Types of Transmembrane Helices Using SOSUI System
There are many amino acid sequences in proteomes which are not homologous to any other sequences. Therefore, methods to classify proteins independent of the sequence homology are strongly required for computational analysis of proteomes. Proteins may be divided into two categories: soluble and membrane proteins. Since membrane proteins are characterized by the existence of long hydrophobic tran...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2005
ISSN: 0021-9258
DOI: 10.1074/jbc.m413536200